Apart from the Olympics, there are other signs that summer habits might be changing. According to the Los Angeles Times, 58 percent of U.S. homes watched prime-time television in August 2011, up from 56 percent in August 2009. Some of the change is surely driven by all that new cable content, but there is a technological component, too. Patricia McDonough, senior vice president of planning policy and analysis at Nielsen, told me that increasing adoption of DVRs?about half of U.S. households now have one?means the summer ratings dip is less pronounced than in the past: ?At 8 o?clock we may still be outdoors, but by 9 or 10, we may be in and watching programming. Now we don?t have to miss our favorite show if it?s on at 8, because we can DVR it and watch it when we get back.? And it?s not just DVRs. TV catch-up service Hulu has announced 10 original or exclusive programs that will unspool over the summer. What?s more, as of 2012, most mobile phones are smartphones, which means viewers can take their TV habits beyond the living room. ?If I?m out in the backyard barbecuing, I can still be watching the ball game. So the television is going with us this year probably more than ever before, and that?s a trend that will continue,? says McDonough. Right now, TV networks can?t sell advertising against that al fresco viewing, because it doesn?t show up in the standard Nielsen ratings, but the company has recently established a smartphone panel and other cross-platform measurements, so that may soon change.
CNBC's Jon Fortt reports the latest details from the "All Things Digital Conference", including speculation on Apple's unveiling a revolutionary iTV. Also, Lawrence Bossidy, former Honeywell chairman & CEO, discusses the difference between the leadersh...
Plumbing Atlanta is one thing that no homeowner in Atlanta should do on their own as a DIY project. Hiring a professional Atlanta plumber can certainly make your life much easier when plumbing issues arise plus finding the right Atlanta plumber for the plumbing job is essential for making sure that your plumbing problem is fixed and not made worse.
Below noted are reasons for hiring a professional plumber Atlanta.
? No developer will hire uncertified Atlanta plumbers, when they build houses they have to make sure that their house plans are certified from each and every angle. This precaution ensures that their investors will be assured of top-notch quality plumbing work. No investor will touch any property if the individuals involved are not certified. Professional Atlanta plumbers can guarantee that if there is a back job which needs to be done, it will not cost investors any extra amount.
? Professional plumbers Atlanta certifying plumbing for any building or house and can guarantee to the owner plus investor that they can have the properties insured. No insurance firm will allow insurance coverage if the properties are not certified correctly. If in case there is insurance coverage made and certain unfortunate event occurs then there will be penalties which developers and homeowners will not be able to afford.
? It is only a professional plumber Decatur who can guarantee that his plumbing work will not bring about any issues plumbing-wise. If there are clogs or leaks it is part of his plumbing service to fix them, without any extra costs.
? Hiring a professional plumber Atlanta to fix any plumbing issue will be more cost effective even if his fees might be a bit steep. At least with a professional plumber Atlanta, there would be no work which might require corrections as normally happens when homeowners make an effort to fix the plumbing problem themselves and they end up making more of a mess. When this happens, the professional Atlanta plumber hired to do the corrections would normally charge extra.
? Homeowners in Atlanta who only hire professional Atlanta plumbers will get an official receipt for the plumbing work. If the plumbing work is for home improvement purposes then the expenses can be tax deductable or it could even be added on to the value of your house. This way not just are the taxes taken cared of but homeowners who want to sell their house can get a better price for it.
I am sure after going through this piece of information you agree that you must hire a professional Atlanta plumber. If you are looking for superb Atlanta plumbing then I would suggest getting in touch with The Pink Plumber. Each and every Atlanta plumber Atlanta at this company is known to do a great job. This company completely understands that plumbing problems can happen at anytime which is why they are available 24 hours a day 7 days a week for their clients. Apart from Atlanta plumbing this company has a great deal of know-how when it comes to air conditioning, water heaters Atlanta and also septic tanks. For more details please visit their website at http://www.thepinkplumber.com/.
About The Author
A service provider from The Pink Plumber is the author of this article. Find more information about Atlanta Plumber, Plumber Atlanta, Plumber Decatur and Water Heaters Atlanta at The Pink Plumber. They offer reliable plumbing services in Atlanta, Georgia, Call (404) 222-7465 or go to website at The Pink Plumber.
Sales Management Training and techniques?: Help the Sales Staff to perform Their Best Every year, all type of businesses globally spend a lot of money in advertisement, however are they paying enough in sales training courses? Sales management training is a vital part of a company, especially if it's a large 1. Those who manage sales force training every year definitely observe its advantages and its impact on product sales results. Sales training courses are crucial because every business needs the best sales force to sell its products or services. Keep in mind that the performance of whole salesforce is essential for the success of business . Without having an effective business system including a competent staff, the company will fail to achieve its temporary or long term predicted objectives. The Benefit of Investing in Sales Training Courses: The benefit of investing in sales management training is associated with the ability to emphasis each person's minds on worthwhile tasks of the sales process. This involves communication abilities, inter-personal capability, how to offer deals, the way to close deals and other significant aspects of the sales process. Obviously, each business has its own style of attaining customers. Therefore, it is necessary to train employees in order to handle their own target audience. This is necessary because every organization includes a variety of clients. The problem right now includes selecting the most appropriate kind of sales consultancy for the staff. Firstly, the sales courses should be appropriate for your corporation as well as your target audience. Researchers have identified that approximately 25 percent of the whole sales force contributes to about 90?% of the final amount of sales. In this case, it is widely considered that most of those who from the sales team are not qualified sufficient to accomplish the given goals. It may also be determined that about Seventy five percent of these have to be trained further or even they may have chosen the wrong occupation. Yet, the importance of sales training courses can be identified from the previously mentioned example. With regard to companies who would like to improve their sales outcomes, it's important to conduct exploration upon which business management courses they should obtain. The best way to determine this is to review the methods their major competitors are applying. Even when your sales staff have years of sales experience, it's still need to study newer methods and strategies that work well. Recognise that selling methods also develop along with modern technology. Using the well-known as well as increasing use of the Internet, social networks and cell phones, firms will likely fail to get along with the competition if they do not understand the strength of these kinds of new promoting media marketing. Several sales training courses deal with how to use technology as a medium for the purpose of selling. Sales people are like technicians who need to improve their expertise. Without proper and sufficient sales management training, your output will be less likely to boost. Hence, do not look at sales training courses as an further cost, rather an investment. Sales team and managers as well need to have sales consultancy to enhance their knowledge and skills in selling, even if they boast many years of experience in any industry. To tactically improve your organization, investing in Sales training courses will provide the very best roi. To get the entire selection of advantages from our sales management training, sales courses as well as Sales Training UK, visit www.BigRockhq.com
Study reveals how the world's first drug for amyloid disease worksPublic release date: 29-May-2012 [ | E-mail | Share ]
Contact: Mika Ono mikaono@scripps.edu 858-784-2052 Scripps Research Institute
LA JOLLA, CA May 29, 2012 Scientists from The Scripps Research Institute and Pfizer Inc. have published a new study showing how a new drug called tafamidis (Vyndaqel) works. Tafamidis, approved for use in Europe and currently under review by the US Food and Drug Administration (FDA), is the first medication approved by a major regulatory agency to treat an amyloid disease, a class of conditions that include Alzheimer's.
Tafamidis treats a deadly nerve disease caused by transthyretin (TTR) amyloid fibril formation, or the accumulation of abnormal assemblies of the TTR protein. The drug inhibits TTR aggregation, and clinical trials have shown that it delays the typical progression of nerve destruction in polyneuropathy patients.
"The details in this new paper, combined with clinical trial data, show for the first time that an amyloid disease can be successfully treated by reducing the rate of amyloid formation," said Jeffery W. Kelly, chair of the Department of Molecular and Experimental Medicine, the Lita Annenberg Hazen Professor of Chemistry, and member of the Skaggs Institute for Chemical Biology at Scripps Research. Kelly is a senior author of the new paper, which appears in an advance, online Early Edition issue of Proceedings of the National Academy of Sciences on May 29, 2012.
An Array of Progressive Symptoms
While the naturally occurring or "wild type" transthyretin protein is prone to aggregate in older people causing cardiac disease, a variety of destabilizing mutations lead either to a primary cardiomyopathy or to early onset forms of polyneuropathy, known as TTR familial amyloid polyneuropathy, affecting about 10,000 people worldwide.
Familial amyloid polyneuropathy compromises the peripheral and autonomic nervous systems, with symptoms including sensory deprivation and pain, muscle weakness and wasting, and alternating constipation and diarrhea. In some familial amyloid polyneuropathy patients, cardiomyopathy can present later in the course of the disease.
In transthyretin amyloid diseases that present primarily as a cardiomyopathy, doctors have been able to stave off heart failure with a liver and heart transplant; familial amyloid polyneuropathy patients receiving a liver transplant can benefit, since the liver is the primary source of mutant, disease-associated TTR. For the 90 percent of patients surviving transplantation, this surgical form of gene therapy slows familial amyloid polyneuropathy progression, but does not stop it as the wild type transthyretin protein can continue to form amyloid.
Left untreated, the TTR amyloidoses are relentlessly progressive and inevitably fatal, with a course of about a decade from initial symptoms to death.
The Search for Treatments
Kelly began searching for TTR-amyloidogenesis-inhibitors in the mid 1990s, and a few years later began to focus on a family of TTR-binding compounds, the so-called benzoxazoles, whose basic design would further be elaborated into tafamidis using a structure-based drug design paradigm. In 2003, Kelly co-founded a Cambridge, Massachusetts-based biotechnology startup, FoldRx Pharmaceuticals (now a fully owned subsidiary of Pfizer), to develop these compounds and optimize one of them into an orally available drug for the treatment of the TTR amyloidoses. The result was tafamidis meglumine, whose preclinical tests remained unpublished until now.
Kelly and his colleagues designed tafamidis to bind to the natural, functional TTR structure (mutant and wild type), in a way that prevents it from deviating from this natural, functional form into the amyloid state. TTR's natural, functional form is a "tetramer" made from four copies of the protein. Amyloidosis occurs when these tetramers come apart and the individual TTR proteins ("monomers") undergo shape changes enabling them to misassemble into dysfunctional amyloid aggregates. Included in the TTR aggregate distribution are amyloid fibrilsprotein stacks made from millions of TTR monomersalthough researchers suspect that smaller, shorter-lived pre-amyloid aggregates do more direct damage to nerve cells and nerve fibers.
The early onset TTR amyloidoses are caused by inherited TTR mutations that weaken the tetramers' ability to stick together, producing monomers more likely to aggregate into amyloids and other aggregate structures. Fortunately, the TTR tetramer, which is the backup carrier of the thyroid hormone thyroxine through the bloodstream, has two unoccupied thyroxine-binding sites along its longest and weakest seam. Kelly and his colleagues designed tafamidis to grab either of these thyroxine-binding sites, in a way that bridges the seam and helps keep the tetramer from coming apart.
A Stabilizing Influence
The newly published molecular and structural data show that tafamidis does indeed stabilize TTR tetramers, under normal physiological conditions in the bloodstream and even under abnormal conditions when they would be much more likely to fall apart and reassemble as amyloids. Tafamidis has this stabilizing effect on tetramers of the normal "wild-type" TTR protein as well as on those made from disease-associated mutant and wild type TTR subunits.
"There are more than a hundred TTR mutations that cause amyloidosis, but the vast majority of those TTRs are capable of being bound by tafamidis and held in the natural tetramer state," said Kelly.
Throughout the development of tafamidis-type compounds, Kelly and his colleagues collaborated with the Scripps Research laboratory of Ian A. Wilson, who is Hansen Professor of Structural Biology and a member of the Skaggs Institute at Scripps Research. The Wilson laboratory specializes in the use of X-ray crystallography to determine the atomic structures of interacting proteins. Whenever a small molecule stabilizer of TTR was generated that afforded interesting biochemical stabilization, Wilson's team analyzed its structure. "By the end, we had determined more than 30 small molecule stabilizerTTR structures, in an effort to generate tafamidis and identify the molecular interactions that lead to stabilization of the natural TTR tetramer," said Stephen Connelly, a Wilson laboratory staff scientist who performed these structural studies and who was a co-author the paper.
The small molecule benzoxazole, tafamidis, that ultimately entered clinical trials was optimized for several criteria, including its ability to stabilize the TTR tetramer's weakest seam. "We found that one end of the tafamidis structure fits neatly into the tetramer's hydrophobic thyroxine-binding pocket, while at the other end it binds to nearby polar amino acids, both types of interactions bridging or stabilizing the two halves of the tetramer," Connelly said. The drug's stabilizing force greatly reduces the rate at which these tetramers come apart, and in so doing greatly reduces the rate of amyloid formation.
Tafamidis is considered an "orphan" drug because its initial intended treatment population is the relatively small polyneuropathy population. However, even wild-type TTR forms amyloid in 10 to 20 percent of the growing elderly populationleading to cardiomyopathy. Thus, this condition, and drugs such as tafamidis that can treat it, could be of growing interest to the pharmaceutical industry.
###
In addition to Kelly, Wilson, and Connelly, co-authors of the paper, "Tafamidis, a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade," are Michael DeVit and Jeff Packman of FoldRx Pharmaceuticals; Lan Wang of Novartis Institutes for Medical Research in Cambridge, Mass.; Charlotte Weigel and James Fleming from Pfizer's Orphan and Genetic Diseases Research Unit in Cambridge, Mass.; Theodore R. Foss of Life Technologies in Beverly, Mass.; and Evan T. Powers and R. Luke Wiseman of Scripps Research.
The studies described in the new paper were funded by FoldRx, the National Institutes of Health, and the Skaggs Institute of Chemical Biology at Scripps Research.
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?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Study reveals how the world's first drug for amyloid disease worksPublic release date: 29-May-2012 [ | E-mail | Share ]
Contact: Mika Ono mikaono@scripps.edu 858-784-2052 Scripps Research Institute
LA JOLLA, CA May 29, 2012 Scientists from The Scripps Research Institute and Pfizer Inc. have published a new study showing how a new drug called tafamidis (Vyndaqel) works. Tafamidis, approved for use in Europe and currently under review by the US Food and Drug Administration (FDA), is the first medication approved by a major regulatory agency to treat an amyloid disease, a class of conditions that include Alzheimer's.
Tafamidis treats a deadly nerve disease caused by transthyretin (TTR) amyloid fibril formation, or the accumulation of abnormal assemblies of the TTR protein. The drug inhibits TTR aggregation, and clinical trials have shown that it delays the typical progression of nerve destruction in polyneuropathy patients.
"The details in this new paper, combined with clinical trial data, show for the first time that an amyloid disease can be successfully treated by reducing the rate of amyloid formation," said Jeffery W. Kelly, chair of the Department of Molecular and Experimental Medicine, the Lita Annenberg Hazen Professor of Chemistry, and member of the Skaggs Institute for Chemical Biology at Scripps Research. Kelly is a senior author of the new paper, which appears in an advance, online Early Edition issue of Proceedings of the National Academy of Sciences on May 29, 2012.
An Array of Progressive Symptoms
While the naturally occurring or "wild type" transthyretin protein is prone to aggregate in older people causing cardiac disease, a variety of destabilizing mutations lead either to a primary cardiomyopathy or to early onset forms of polyneuropathy, known as TTR familial amyloid polyneuropathy, affecting about 10,000 people worldwide.
Familial amyloid polyneuropathy compromises the peripheral and autonomic nervous systems, with symptoms including sensory deprivation and pain, muscle weakness and wasting, and alternating constipation and diarrhea. In some familial amyloid polyneuropathy patients, cardiomyopathy can present later in the course of the disease.
In transthyretin amyloid diseases that present primarily as a cardiomyopathy, doctors have been able to stave off heart failure with a liver and heart transplant; familial amyloid polyneuropathy patients receiving a liver transplant can benefit, since the liver is the primary source of mutant, disease-associated TTR. For the 90 percent of patients surviving transplantation, this surgical form of gene therapy slows familial amyloid polyneuropathy progression, but does not stop it as the wild type transthyretin protein can continue to form amyloid.
Left untreated, the TTR amyloidoses are relentlessly progressive and inevitably fatal, with a course of about a decade from initial symptoms to death.
The Search for Treatments
Kelly began searching for TTR-amyloidogenesis-inhibitors in the mid 1990s, and a few years later began to focus on a family of TTR-binding compounds, the so-called benzoxazoles, whose basic design would further be elaborated into tafamidis using a structure-based drug design paradigm. In 2003, Kelly co-founded a Cambridge, Massachusetts-based biotechnology startup, FoldRx Pharmaceuticals (now a fully owned subsidiary of Pfizer), to develop these compounds and optimize one of them into an orally available drug for the treatment of the TTR amyloidoses. The result was tafamidis meglumine, whose preclinical tests remained unpublished until now.
Kelly and his colleagues designed tafamidis to bind to the natural, functional TTR structure (mutant and wild type), in a way that prevents it from deviating from this natural, functional form into the amyloid state. TTR's natural, functional form is a "tetramer" made from four copies of the protein. Amyloidosis occurs when these tetramers come apart and the individual TTR proteins ("monomers") undergo shape changes enabling them to misassemble into dysfunctional amyloid aggregates. Included in the TTR aggregate distribution are amyloid fibrilsprotein stacks made from millions of TTR monomersalthough researchers suspect that smaller, shorter-lived pre-amyloid aggregates do more direct damage to nerve cells and nerve fibers.
The early onset TTR amyloidoses are caused by inherited TTR mutations that weaken the tetramers' ability to stick together, producing monomers more likely to aggregate into amyloids and other aggregate structures. Fortunately, the TTR tetramer, which is the backup carrier of the thyroid hormone thyroxine through the bloodstream, has two unoccupied thyroxine-binding sites along its longest and weakest seam. Kelly and his colleagues designed tafamidis to grab either of these thyroxine-binding sites, in a way that bridges the seam and helps keep the tetramer from coming apart.
A Stabilizing Influence
The newly published molecular and structural data show that tafamidis does indeed stabilize TTR tetramers, under normal physiological conditions in the bloodstream and even under abnormal conditions when they would be much more likely to fall apart and reassemble as amyloids. Tafamidis has this stabilizing effect on tetramers of the normal "wild-type" TTR protein as well as on those made from disease-associated mutant and wild type TTR subunits.
"There are more than a hundred TTR mutations that cause amyloidosis, but the vast majority of those TTRs are capable of being bound by tafamidis and held in the natural tetramer state," said Kelly.
Throughout the development of tafamidis-type compounds, Kelly and his colleagues collaborated with the Scripps Research laboratory of Ian A. Wilson, who is Hansen Professor of Structural Biology and a member of the Skaggs Institute at Scripps Research. The Wilson laboratory specializes in the use of X-ray crystallography to determine the atomic structures of interacting proteins. Whenever a small molecule stabilizer of TTR was generated that afforded interesting biochemical stabilization, Wilson's team analyzed its structure. "By the end, we had determined more than 30 small molecule stabilizerTTR structures, in an effort to generate tafamidis and identify the molecular interactions that lead to stabilization of the natural TTR tetramer," said Stephen Connelly, a Wilson laboratory staff scientist who performed these structural studies and who was a co-author the paper.
The small molecule benzoxazole, tafamidis, that ultimately entered clinical trials was optimized for several criteria, including its ability to stabilize the TTR tetramer's weakest seam. "We found that one end of the tafamidis structure fits neatly into the tetramer's hydrophobic thyroxine-binding pocket, while at the other end it binds to nearby polar amino acids, both types of interactions bridging or stabilizing the two halves of the tetramer," Connelly said. The drug's stabilizing force greatly reduces the rate at which these tetramers come apart, and in so doing greatly reduces the rate of amyloid formation.
Tafamidis is considered an "orphan" drug because its initial intended treatment population is the relatively small polyneuropathy population. However, even wild-type TTR forms amyloid in 10 to 20 percent of the growing elderly populationleading to cardiomyopathy. Thus, this condition, and drugs such as tafamidis that can treat it, could be of growing interest to the pharmaceutical industry.
###
In addition to Kelly, Wilson, and Connelly, co-authors of the paper, "Tafamidis, a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade," are Michael DeVit and Jeff Packman of FoldRx Pharmaceuticals; Lan Wang of Novartis Institutes for Medical Research in Cambridge, Mass.; Charlotte Weigel and James Fleming from Pfizer's Orphan and Genetic Diseases Research Unit in Cambridge, Mass.; Theodore R. Foss of Life Technologies in Beverly, Mass.; and Evan T. Powers and R. Luke Wiseman of Scripps Research.
The studies described in the new paper were funded by FoldRx, the National Institutes of Health, and the Skaggs Institute of Chemical Biology at Scripps Research.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
- WWE is currently advertising the following main events for their upcoming shows in Japan:
August 9: * Sheamus vs. Kane for the World Heavyweight Championship with John Ace as either special referee or special enforcer. * Randy Orton vs. Alberto Del Rio in a No-DQ match.
August 10: * Fatal 4-Way for the World Heavyweight Championship involving Sheamus, Kane, Orton and Del Rio * They are also still advertising Big Show vs. Cody Rhodes for the IC Championship for both nights
* Card is subject to change.
- Brock Lesnar was in attendance at Saturday night?s UFC 146 event in Las Vegas. Lesnar was featured on television moments before the main event, watching UFC Heavyweight Champion Junior dos Santos defeat Frank Mir to retain the UFC Championship. UFC mentioned him via Twitter and also posted a picture of him at the event.
PHOTOS: BROCK LESNAR AT SATURDAY?S UFC 146 PPV!! (??)
If you're planning on hosting a barbecue to celebrate the long weekend, Union County merchants?Savory Spice Shop?and CoolVines?are offering some suggestions to help get your party started.?
Savory's co-owner Becky Solheim shared some of the East Broad Street shop's top recipes to ring in the unofficial start of summer.?
Notes: To make an extra spicy jerk paste, bring remaining marinade, meat bits and all, to a boil in a sauce pan. Stir continuously until it thickens. Serve on the side for those who prefer even more heat.
Directions: Mix ingredients together and marinate chicken (we prefer boneless, skinless chicken thighs) or meat of choice for 4-12 hours. Grill for the best flavor.
Serving Suggestions: Serve with jerk paste (see notes) for that extra kick. Also, make coconut rice by combining 1 cup Jasmine rice and 1 14 fluid ounce can coconut milk in a saucepan and bring to a boil. Reduce to a very low simmer, cover and let cook for 20 minutes. Uncover and stir well, then let sit, covered, for 10 minutes. To punch up the coconut flavor, add 1/3 tsp.?coconut extract.
Yields:?Makes enough for 2-3 lbs. of meat.
Red Rocks Hickory Smoke & Beer BBQ Sauce Ingredients: 6-8 tbsp.?Red Rocks Hickory Smoke Seasoning 1/2 cup white wine vinegar 4 tbsp. vegetable oil 2/3 cup beer 6 tbsp. ketchup
Directions: Stir ingredients together in a sauce pan. Bring to a boil then simmer for 7-10 minutes.
Serving Suggestions: Try on beef, chicken and pork.
Yields:?1 Cup
Stop by the shop for more ideas.
Drinks, anyone??
Here are some fun, fresh, crowd-pleasing, and grill-friendly suggestions from the CoolVines gang:?
Ros?s are perfect for outdoor sipping and will accompany a variety of Spring and summer fare. In particular, we are recommending the?Commanderie de la Bargemone Ros??from Provence. Its delicate aromatics and bright, crisp acidity are a great match for anyone looking to be refreshed and impressed.?
Merlot-based Bordeaux wines greatly complement and enhance the flavor of grilled meats. Merlot is the most widely-planted grape in France's Bordeaux region and there a ton of amazing, high-quality wines priced at $15 and under that will steal the show at any BBQ. We highly recommend the?Chateau Rollan de BY Comtesse 2009--an absolute beauty with unsurpassed value."?
CoolVines' Lauren Ramos explained there is currently a huge craft can movement going on in the beer world.?
"There are a lot of craft brewing companies out there that have opted to can their brews. We have Leinenkugel's Summer Shandy out of Wisconsin, an array of offerings from Nantucket's Cisco Brewers, and Brooklyn Brewery's Summer Ale.? They all come in 12-pack cans, which chill faster, are more affordable, and easier on the environment. ?
"You can also choose to go local (and who doesn't want to do that?)! We actually have assistant brewer, Brent Rusche from New Jersey's very own?Cricket Hill Brewery?coming to conduct a tasting at CoolVines this Sunday from 2-5 p.m.? We'll be tasting their New Jersey Breakfast Ale and Colonel Blides Cask Ale among others."
For more information, contact CoolVines at 908-232-5050 and Savory Spice Shop at 908-264-8947.?
GARLAND, Texas -- High school students have raised $10,000?for the family of?a convenience store clerk, known as "Grandma" to?many in the Garland community, who was set on fire during a robbery attempt.
Nancy Harris, 76, died Friday night, nearly a week after the attack at the Fina gas station where she worked in South Garland.
On Saturday,?students from South Garland High School?returned to the place of the attack to hold a car wash and raise money for her family.
Read the original report at NBCDFW.com
"I was just devastated. Its kind of outlandish that someone would go out of their way to do this,"?said Dylan Stooksberry, president of the school's student council. "To have that happen to someone who you know, to?a face that you know, to a friend, it's devastating."?
"It hurts deep down and honestly if someone is going to go out of their way to do something bad like that, I am going to go out of my way to do something nice," said Stooksberry.
The Fina gas station is just a block from their school. Many students, like DJ Valderrama, personally knew Harris.
"I came in the gas station and she showed me so much kindness by giving me a free drink,"?Valderrama said. "Whenever somebody shows you that kind of kindness if affects your life, really."
Watch the most-viewed videos on msnbc.com
Despite the tragedy on Sunday at the Fina gas station, many students told NBC 5 that the incident has brought the community closer together.
Many?hoped this fundraiser will help honor Harris.
"I know Ms. Harris is looking down on us right now, I know she is happy," said Valderrama.
Matthew Johnson is charged with attempted capital murder in connection with this case. Those charges could be upgraded because Ms. Harris has died.
More content from msnbc.com and NBC News:
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A course for US military officers has been teaching that America?s enemy is Islam in general and suggesting that the country might ultimately have to obliterate the Islamic holy cities of Mecca and Medina without regard for civilian deaths, following second world war precedents of the nuclear attack on Hiroshima.
The Pentagon suspended the course in late April when a student objected to the material. The FBI also changed some agent training last year after discovering that it, too, was critical of Islam.
?They hate everything you stand for and will never coexist with you, unless you submit,? the instructor, Lieutenant Colonel Matthew Dooley, said in a presentation last July for the course at Joint Forces Staff College in Norfolk, Virginia. The college, for professional military members, teaches mid-level officers and government civilians on subjects related to planning and executing war.
Dooley also presumed, for the purposes of his theoretical war plan, that the Geneva conventions that set standards of armed conflict, are ?no longer relevant?.
He adds: ?This would leave open the option once again of taking war to a civilian population wherever necessary (the historical precedents of Dresden, Tokyo, Hiroshima, Nagasaki being applicable to the Mecca and Medina destruction decision point).?
His war plan suggests possible outcomes such as ?Saudi Arabia threatened with starvation ? Islam reduced to cult status?.
A copy of the presentation was obtained and posted online by Wired.com?s Danger Room blog. The college did not respond to the Associated Press? requests for copies of the documents, but a Pentagon spokesman authenticated the documents. Dooley still works for the college, but is no longer teaching, said the joint chiefs of staff chairman, General Martin Dempsey. Dooley has refused to comment.
A military service record summary provided by army human resources at Fort Knox, Kentucky, shows that Dooley was commissioned as a second lieutenant upon graduation from the US military academy at West Point, New York, in May 1994. He has served tours in Germany, Bosnia, Kuwait and Iraq. He has numerous awards including a Bronze Star medal, the fourth-highest US combat award.
In what he termed a model for a campaign to force a transformation of Islam, Dooley called for ?a direct ideological and philosophical confrontation with Islam?, with the presumption that Islam is an ideology rather than just a religion.
He further asserted that Islam has already declared war on the west, and the US specifically.
?It is therefore illogical? to continue with the current US strategy, which Dooley said presumes there is a way of finding common ground with Islamic religious leaders, without ?waging near total war?.
The course on Islam had been taught since 2004, but was not part of the required core curriculum. It was offered five times a year, with about 20 students each time.
Though Dooley has been teaching at the college since August 2010, it was unclear when he took on that particular class, called Perspectives on Islam and Islamic Radicalism.
The joint staff suspended the course after it had received a student complaint, and within days Dempsey ordered all service branches to review their training to ensure other courses do not use anti-Islamic material.
On Thursday, Dempsey said the material in the Norfolk course was counter to American ?appreciation for religious freedom and cultural awareness?.
?It was just totally objectionable, against our values, and it wasn?t academically sound,? Dempsey said. ?This wasn?t about ? pushing back on liberal thought; this was objectionable, academically irresponsible.?
He described his purpose as generating ?dynamic discussion and thought?, while noting that his ideas and proposals are not official US government policy and cannot be found in any current official defence department documents.
A Pentagon inquiry is seeking to determine whether someone above the professor?s level is supposed to approve course materials and whether that approval process was followed in this case, said Colonel Dave Lapan, a spokesman for Dempsey.
The problem of negative portrayals of Islam in federal government is not new. A six-month review the FBI launched into agent training material uncovered 876 offensive or inaccurate pages that had been used in 392 presentations, including a PowerPoint slide that said the bureau can sometimes bend or suspend the law in counterterror investigations.
The wife of a U.S. soldier stationed at Schofield Barracks, Hawaii, has released a song, "There You Go Again" dealing with the all too familiar heartache military families face when the military member deploys.
The song, by Olivia Perez-Breland is available on iTunes, and the artist said she will donate half the proceeds to the Fisher House Foundation, which supports military families.
A video of the song posted on YouTube last month has garnered more than 43,000 hits and seems to be striking a chord among listeners.
"This song gave me chills and tears," one comment said. "My husband and I just got done with a deployment a few months ago and It made me think of everything I thought about when he was gone. This is now my favorite song."
Perez-Breland said she produced the video using Schofield soldiers preparing to deploy to Afghanistan and their families bracing for the long separation.
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Microsoft says it does send copyright-related takedown requests to its own search engine, Bing, in addition to the multitude of requests that it sends to Google.
This comes on the heels of yesterday?s news that Microsoft is the number one submitter of copyright-related URL removal requests to Google. It sent more than 500,000 such requests in the past month, asking Google to remove URLs that host pirated copies of Microsoft products and other copyright-infringing material.
TechDirt pointed out that some of the URLs that Microsoft asked Google to remove were still appearing in Bing?s search results.
A Microsoft spokesperson explained that to us today, saying that it?s because the infringing URLs hadn?t been indexed in Bing when the takedown notices were sent:
Microsoft sends takedown notices to search engines, including Bing, only after it verifies that content has been indexed. At the time of the takedown notice in question, the link to the particular piece of infringing content was not included in Bing?s search results.
The TorrentRoom.com URL that TechDirt showed as listed in Bing yesterday is no longer showing in Bing?s index.
In this case, then, it appears that Google?s speed in indexing URLs ? which it often does more quickly than Bing ? is the main reason why Google had received the takedown request in question before Bing did.
But I have to add ? Bing isn?t going to make many friends with related searches like the one above that helps searchers find a site to download Spartacus.
Related Topics: Legal: Copyright | Microsoft: Bing | Top News
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SANTO DOMINGO, Dominican Republic (AP) - Dominican relief pitcher Juan Carlos Oviedo says he has his U.S. visa, and will able to rejoin the Miami Marlins in August after serving a suspension from Major League Baseball.
Oviedo was caught playing under the fake name of Leo Nunez and spent the offseason in the Dominican Republic clearing up his immigration status. He said Friday that he had received a visa from the U.S. government and would be in South Florida on Monday.
His suspension will be for eight weeks, a person familiar with the case said. The person spoke on condition of anonymity because the suspension hasn't been announced.
Marlins reliever Edward Mujica, who spoke by phone with Oviedo, said his teammate is excited about rejoining the Marlins.
"He's happy, and I'm happy for him," Mujica said. "He had a bad secret and didn't say anything to anybody, and he's sad about that. Now it's good because everybody knows his real name. But it's going to be hard to call him J.C., you know?"
Oviedo, who turned professional in 2000, has said he used a fake name since he was young so he could say he was old enough to sign his first contract.
He played under the name Leo Nunez for seven major league seasons and had 36 saves and a 4.06 ERA in 68 games for the Marlins in 2011.
They acquired All-Star closer Heath Bell in the offseason, and Oviedo is expected to be given a setup role.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Who deserves some early awards?
DeMarco: David Wright's hot bat ? he's hitting .405 ? makes him the pick for NL MVP thus far. But that's just for starters in our feature.
Pirates blank Cubs for 10th straight loss
PITTSBURGH (AP) - A.J. Burnett and four relievers worked out of trouble all game and the Pittsburgh Pirates sent the Chicago Cubs to their 10th straight loss with a 1-0 victory on Friday night.
On Thursday 24th May, a party from the Queen Alexandra Hospital Home had the privilege of attending a very special and honourable event ? the Royal Garden Party at Buckingham Palace. The party consisted of Chris Binns, Dixie Dean, Clifford Impett, Rene Barclay, Andy Watkins, Graham Brown and Ken Wormsley.
After a quick photo, residents and staff all dressed to the nines, climbed aboard the QAHH coach and departed for Buckingham Palace.
Every summer, Her Majesty the Queen hosts a number of Royal Garden Parties where guests have the rare chance to see the Royal family, whilst enjoying tea in the beautiful gardens at Buckingham Palace. The garden parties are held to recognise and reward outstanding public service.
Residents will take tea and cakes on the grounds of Buckingham Palace and bask in the sunshine as temperatures at the royal residence are set to soar to 28C. In attendance will be the Royal Family and Lords, Earls, Dukes, Duchesses and Ladies from the aristocratic British Society as well as a host of celebrities.
Activities and outings are a major part of life at QAHH. Visits in the past year have included? trips to London museums, the London Eye, Twickenham rugby ground for a number of international matches, Thames boat ride with the most popular being the Buckingham Palace Garden Party. ?It is a huge honour to be invited to the Garden Party, we all look forward to it.? commented one of our residents.
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I am being charged for criminal damaging for keying a car. I did not key the car but someone i was with did. The guy's who's car was damaged told the police he thinks I did it, so they called me in for fingerprinting. I went and got prints because I knew they weren't mine and my original statement says I wasnt nowhere near his apartment. Well the next day the police said a cop ran my plates that night in his apartment complex and showed me the cop's statement which also stated I was with another female. So I told the truth about me not keying his car but the person I was with did. I am being charged and I go to court next week. How should I plea? What should I do?
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Accomplis in criminal damaging charged w/ 2nd degree misdemeanor
? Posted by Rolando Trentini on May 24, 2012 in Blog | 0 comments
For quite a while now, bargain hunters have been able to take their time combing through Evansville foreclosure listings. They?ve been looking for the kind of terrific real estate bargains that the last few years have provided ? and there have been plenty. But recent signs show that it may be time for them to step up their efforts.
According to ReatyTrac, the outfit that reports on current real estate activity of all kinds, banks are increasingly leaning toward short sales as a way to handle defaulted properties. There are good reasons why they would prefer short sales over the foreclosure track. You would expect that if that trend is for real, we should see a decline in the number of foreclosure-related notices being issued. Last month, that is exactly what happened.
In April, fewer than 190,000 of the notices were reported. That makes it the lowest monthly total in 5 years (and a decline of 5% from March). In other words, although it takes some time for a foreclosure to occur, the writing seems to be on the wall: the high water mark in foreclosures may well have been passed.
Another sign: the average price of completed foreclosures rose from the year?s average of $226,953 to $256,027. Lower supply, higher prices ? if the early trend continues,local foreclosure bargain hunters may soon find themselves having to hunt a bit harder.
There are many online resources that provide foreclosure lists: properties that are in good shape as well as distressed foreclosure properties, pre-foreclosure properties, REO foreclosures and foreclosure auctions. Anyone thinking about taking advantage of the bargains that are still out there (and they ARE still out there) should consider consulting an experienced Evansville agent to help with the process.
First and foremost, we can provide you with a current and accurate foreclosure list. There are many web sites out there that claim to list foreclosed properties, but most of them charge fees for their listings, and sometimes contain little or no contact information for accessing a property (or worse, are inaccurate). Licensed real estate agents have the resources to obtain an accurate, timely list, as well as the experience in targeting the correct contact people.
Your agent can also be a guide through the sometimes tricky process of purchasing a foreclosed house. Many properties on the foreclosure list have not been well maintained; the lender may try to get more for the house than it is actually worth. If you intend to improve a property through your own sweat equity, our first-hand knowledge of local market values can help you project a property?s future value, too?either as an income-producing rental or to sell for profit.
To get the most bang for your buck, make sure to put your search in the hands of a professional. Call me anytime! You can reach me on my cell phone 812-499-9234.
Lindsey Rosman, a doctoral student in the department of psychology at East Carolina University contacted me recently about a confidential online survey she is conducting as part of her research into body image and sexual functioning after breast cancer?.
Lindsey is also a breast cancer survivor, so knows first hand how often quality of life concerns associated with cancer survivorship can be overlooked. In her email to me she writes:
From my perspective as a survivor and as a researcher, these important issues are poorly understood, leaving many women without adequate support and treatment. With support from my faculty supervisor and approval from the Institutional Review Board at East Carolina University, I designed a confidential online survey to examine?body image concerns and long-term sexual adjustment in women diagnosed and treated for early-stage breast cancer. ?
I believe that for most women, their body, and their breasts in particular, are a symbol of what it means to be a woman, mother, and sexual partner. Therefore the impact of breast cancer and its treatment is not limited to changes in physical appearance, but also can include alterations in how survivors perceive themselves as women and partners in an intimate relationship.
By conducting this research, my goal is to learn about women?s body image concerns and sexual experiences in the context of cancer survivorship and ultimately develop an effective intervention to improve the quality of life for survivors and their loved ones.
Please click on the link provided here if you would like to view the confidential online survey:
'Everyone said I was going to have a boy, and they were right!' Snooki tells In Touch magazine. By Gil Kaufman
Jionni LaValle and Snooki Photo: Getty Images
She was hoping for a brood of mini-Snooki's running around under-heel in her home with fiancé Jionni LaValle, but "Jersey Shore" star Nicole "Snooki" Polizzi is overjoyed that her bouncing bundle will wear blue. "Everyone said I was going to have a boy, and they were right!" Snooki told In Touch magazine in the new issue. The baby is due in September and the couple are narrowing down name choices, with the two leading contenders at the moment being Lorenzo or Jionni Jr.
Snooki, 24, told the magazine that she's very excited about the birth of her baby boy, but she admitted that she was hoping for a Jersey girl. "I thought it was going to be a girl. I was hoping it would be, because all girls want girls," she said about her initial disappointment. "It's still my baby, no matter what. I'm excited either way!"
Snooki displays her growing bump on the cover the current issue of the supermarket tabloid, sharing that she's switched from her go-to craving for pickles to cold treats. "I love anything cold and juicy, like Italian ices," she said. In addition to her notoriously rabid sex drive cooling off for now, Snooki said she's also ready to leave some other childish things behind.
"I'm not going to party hard anymore, even after the baby is born," Snooki said. "Being a mom changes you."
Since the rumors first popped up earlier this year, Snooki has flashed the engagement ring she received from LaValle, who has appeared on "Jersey Shore" in the past. Snooki has been filming her spin-off with "Shore" bestie JWoww and an MTV spokesperson said in March that whatever shenanigans the two are up to have been going quite well. "Nicole and Jenni began filming last week and moved into their new digs with animal print furniture in tow ... Things are going great thus far."
Snooki and LaValle began dating a year and a half ago. According to the MTV star, he has plans to pursue a career in education as a teacher. He also works with kids as a wrestling coach.
Share your well-wishes for Snooki and Jionni in the comments below or on our Facebook page!
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Public release date: 29-May-2012
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Microsoft says it does send copyright-related takedown requests to its own search engine, Bing, in addition to the multitude of requests that it sends to Google.
